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PRKCA Break Apart FISH Probe

Empire Genomics’ PRKCA Break Apart FISH Probe is designed to flank the PRKCA gene and is typically used for detecting PRKCA rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
PRKCABA-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PRKCABA-20-AQOR 20 (40 μL) 200 μL
PRKCABA-20-GOGR 20 (40 μL) 200 μL
PRKCABA-20-GORE 20 (40 μL) 200 μL
PRKCABA-20-GRGO 20 (40 μL) 200 μL
PRKCABA-20-GROR 20 (40 μL) 200 μL
PRKCABA-20-GRRE 20 (40 μL) 200 μL
PRKCABA-20-REGO 20 (40 μL) 200 μL
PRKCABA-20-REGR 20 (40 μL) 200 μL

Gene Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: PRKCA

Gene Name: Protein Kinase C Alpha

Chromosome: CHR17: 64298925-64806862

Locus: 17q24.2

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

β-Catenin nuclear expression discriminates deep penetrating nevi from other cutaneous melanocytic tumors from other cutaneous melanocytic tumors

Cutaneous melanocytic tumors can vary significantly in their morphology, especially in early stages. This study aimed to genetically and immunohistochemically distinguish between several cutaneous melanocytic tumor types - deep penetrating nevi (DPN), “blue” melanocytic tumors, Spitz tumors, nevoid and SSM melanomas, and pigmented epithelioid melanocytomas (PEM) – using IHC and FISH. Empire Genomics’ PRKCA break apart was used to detect PRKCA rearrangements in the samples, helping to confirm fusion of the gene in two PEM patients.
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Product Details

Product: PRKCA FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: PRKCA-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping