PPM1D FISH Probe
The PPM1D FISH probe is designed to hybridize to the PPM1D gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
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| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PPM1D-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PPM1D-20-RE | 20 (40 μL) | 200 μL |  |
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| PPM1D-20-GO | 20 (40 μL) | 200 μL |  |
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| PPM1D-20-GR | 20 (40 μL) | 200 μL |  |
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| PPM1D-20-AQ | 20 (40 μL) | 200 μL |  |
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| PPM1D-20-DIG | 20 (40 μL) | 200 μL |  |
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| PPM1D-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: PPM1D
Gene Name: Protein Phosphatase, Mg2+/Mn2+ Dependent 1D
Chromosome: CHR17: 58677543-58743640
Locus: 17q23.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PPM1D FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PPM1D-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping