PLCE1 FISH Probe
The PLCE1 FISH probe is designed to hybridize to the PLCE1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PLCE1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PLCE1-20-RE | 20 (40 μL) | 200 μL |  |
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| PLCE1-20-GO | 20 (40 μL) | 200 μL |  |
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| PLCE1-20-GR | 20 (40 μL) | 200 μL |  |
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| PLCE1-20-AQ | 20 (40 μL) | 200 μL |  |
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| PLCE1-20-DIG | 20 (40 μL) | 200 μL |  |
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| PLCE1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
Gene Details
Gene Symbol: PLCE1
Gene Name: Phospholipase C Epsilon 1
Chromosome: CHR10: 95753745-96088148
Locus: 10q23.33
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PLCE1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PLCE1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping