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NUP98 Break Apart FISH Probe

Empire Genomics’ NUP98 Break Apart FISH Probe is designed to flank the NUP98 gene and is typically used for detecting NUP98 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
NUP98BA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
NUP98BA-20-AQOR 20 (40 μL) 200 μL
NUP98BA-20-GOGR 20 (40 μL) 200 μL
NUP98BA-20-GORE 20 (40 μL) 200 μL
NUP98BA-20-GRGO 20 (40 μL) 200 μL
NUP98BA-20-GRRE 20 (40 μL) 200 μL
NUP98BA-20-ORGR 20 (40 μL) 200 μL
NUP98BA-20-REGO 20 (40 μL) 200 μL
NUP98BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]

Gene Details

Gene Symbol: NUP98

Gene Name: Nucleoporin 98

Chromosome: CHR11: 3696239-3819022

Locus: 11p15.4

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Rapid detection of chromosomal translocation and precise breakpoint characterization in acute myeloid leukemia by nanopore long-read sequencing

Detection of chromosomal translocations has proven crucial for diagnosis and management of acute myeloid leukemia (AML), a cancer known to harbor several distinct gene rearrangements that correlate with disease subtype. In this study, an AML patient was genetically profiled using both conventional karyotyping and next generation sequencing techniques. FISH was also used to detect NUP98 translocations using Empire Genomics’ NUP98 break-apart probe.
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Product Details

Product: NUP98 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: NUP98-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping