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MYBL1 Break Apart FISH Probe

Empire Genomics’ MYBL1 Break Apart FISH Probe is designed to flank the MYBL1 gene and is typically used for detecting MYBL1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
MYBL1BA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
MYBL1BA-20-AQOR 20 (40 μL) 200 μL
MYBL1BA-20-GOGR 20 (40 μL) 200 μL
MYBL1BA-20-GORE 20 (40 μL) 200 μL
MYBL1BA-20-GRGO 20 (40 μL) 200 μL
MYBL1BA-20-GRRE 20 (40 μL) 200 μL
MYBL1BA-20-ORGR 20 (40 μL) 200 μL
MYBL1BA-20-REGO 20 (40 μL) 200 μL
MYBL1BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

The MYB Proto-oncogene Like 1 (MYBL1) gene is located on chr8:67474409 -67525480 at 8q13.1.

Gene Details

Gene Symbol: MYBL1

Gene Name: MYB Proto-oncogene Like 1

Chromosome: CHR8: 67474409-67525480

Locus: 8q13.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Genetic rearrangements, hotspot mutations, and microRNA expression in the progression of metastatic adenoid cystic carcinoma of the salivary gland

Adenoid cystic carcinoma (ACC) is a common salivary gland malignancy. The malignancy is associated with gene fusions between MYB, MYBL1, and NFIB. FISH analysis was used to evaluate any rearrangements in these genes with the use of our break apart probes. It was found through FISH that MYB aberrations were preserved between primary tumors and metastases. Additionally, MYB and NFIB aberrations are preserved in ACC metastatic lesions.
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MicroRNA dysregulation in adenoid cystic carcinoma of the salivary gland in relation to prognosis and gene fusion status: a cohort study

Adenoid cystic carcinoma (ACC) is a frequent malignancy of the salivary gland that is challenging due to an unpredictable clinical course. In hopes of improving this predictability, the association of microRNA with prognostic value in ACC is under study. Along with microRNA tests, FISH analysis was performed with various break apart probes, including our MYLB1 and NFIB probes, to look for any fusion or rearrangement. It was found that several microRNAs were associated with the outcome of ACC and that the most unifying feature of ACC is still involvement of the MYB gene.
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Molecular features of adenoid cystic carcinoma with an emphasis on microRNA expression

Adenoid cystic carcinoma (ACC) is a subtype of salivary gland tumor that can have a poor prognosis. ACC can also be present in lacrimal glands and the breasts with the tumors appearing to be seemingly identical to one another. The phenotypes, genetics, and microRNA expression of ACC in the salivary glands, lacrimal glands, and breasts was characterized in order to better understand the differences between them. Among other characterization tools, FISH analysis was performed with several break apart probes, including our MYBL1 and NFIB probes. The results seemed to indicate that microRNA has value in distinguishing between the tumors.
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Product Details

Product: MYBL1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: MYBL1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping