MYB Break Apart FISH Probe

Empire Genomics’ MYB Break Apart FISH Probe is designed to flank the MYB gene and is typically used for detecting MYB rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days Shipping Time: 1-2 Day Expedited Shipping

Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU	Test Kits	Buffer
MYBBA-20-ORGR (Standard Design)	20 (40 μL)	200 μL
MYBBA-20-AQOR	20 (40 μL)	200 μL
MYBBA-20-GOGR	20 (40 μL)	200 μL
MYBBA-20-GORE	20 (40 μL)	200 μL
MYBBA-20-GRGO	20 (40 μL)	200 μL
MYBBA-20-GROR	20 (40 μL)	200 μL
MYBBA-20-GRRE	20 (40 μL)	200 μL
MYBBA-20-REGO	20 (40 μL)	200 μL
MYBBA-20-REGR	20 (40 μL)	200 μL

Gene Summary

This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Gene Details

Gene Symbol: MYB

Gene Name: MYB Proto-oncogene, Transcription Factor

Chromosome: CHR6: 135502452-135540311

Locus: 6q23.3

FISH Probe Protocols

Protocol, Procedure, or Form Name	Last Modified	Download

Genetic rearrangements, hotspot mutations, and microRNA expression in the progression of metastatic adenoid cystic carcinoma of the salivary gland

Adenoid cystic carcinoma (ACC) is a common salivary gland malignancy. The malignancy is associated with gene fusions between MYB, MYBL1, and NFIB. FISH analysis was used to evaluate any rearrangements in these genes with the use of our break apart probes. It was found through FISH that MYB aberrations were preserved between primary tumors and metastases. Additionally, MYB and NFIB aberrations are preserved in ACC metastatic lesions.

Consistent LEF-1 and MYB Immunohistochemical Expression in Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma: A Potential Diagnostic Pitfall

HPV-related multiphenotypic sinonasal carcinoma (HMSC) is a sinonasal tract neoplasm with a salivary gland tumor-like appearance. The morphologic profile of HMSC is still not fully understood and is under study. One aspect of this morphologic study included FISH analysis with our MYB break apart probes. No rearrangements in MYB were detected by FISH in the cases under study. It was concluded that MYB protein cannot be used to separate adenoid cystic carcinoma from HMSC.

Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma: A Case Report Documenting the Potential for Very Late Tumor Recurrence

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a tumor of the sinonasal tract with a wide morphologic spectrum. A case study of HMSC was under analysis to contribute more information about it to the literature. In addition to other analyses, FISH was done with our MYB break apart probe. It was concluded that HMSC tumors can have a long-term recurrence as well as indolent behavior.

MYB rearrangement and immunohistochemical expression in adenomyoepithelioma of the breast: a comparison with adenoid cystic carcinoma

Adenomyoepithelioma (AME) and adenoid cystic carcinoma (ACC) often occur simultaneously, suggesting that AME may be a related or precursor lesion to ACC. MYB gene rearrangements are frequently reported with ACC. Therefore, the rates of MYB rearrangement were compared between AME and ACC. Translocation of the MYB gene was detected by using FISH analysis with our MYB break apart probe. It was concluded that AMEs do not have MYB gene rearrangement.

Product Details

Product: MYB FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: MYB-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping

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