MC1R FISH Probe
The MC1R FISH probe is designed to hybridize to the MC1R gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MC1R-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MC1R-20-RE | 20 (40 μL) | 200 μL |  |
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| MC1R-20-GO | 20 (40 μL) | 200 μL |  |
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| MC1R-20-GR | 20 (40 μL) | 200 μL |  |
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| MC1R-20-AQ | 20 (40 μL) | 200 μL |  |
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| MC1R-20-DIG | 20 (40 μL) | 200 μL |  |
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| MC1R-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: MC1R
Gene Name: Melanocortin 1 Receptor
Chromosome: CHR16: 89984286-89987385
Locus: 16q24.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MC1R FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MC1R-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping