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MAP3K8 Break Apart FISH Probe

Empire Genomics’ MAP3K8 Break Apart FISH Probe is designed to flank the MAP3K8 gene and is typically used for detecting MAP3K8 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
MAP3K8BA-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MAP3K8BA-20-AQOR 20 (40 μL) 200 μL
MAP3K8BA-20-GOGR 20 (40 μL) 200 μL
MAP3K8BA-20-GORE 20 (40 μL) 200 μL
MAP3K8BA-20-GRGO 20 (40 μL) 200 μL
MAP3K8BA-20-GROR 20 (40 μL) 200 μL
MAP3K8BA-20-GRRE 20 (40 μL) 200 μL
MAP3K8BA-20-REGO 20 (40 μL) 200 μL
MAP3K8BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Gene Details

Gene Symbol: MAP3K8

Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 8

Chromosome: CHR10: 30722949-30750762

Locus: 10p11.23

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations

Melanocytic tumors have been shown to harbor a diverse range of oncogenic kinase fusions, which tend to occur exclusively of one another. A novel MAP3K8 fusion was recently identified in a cohort of spitzoid tumors. This study expanded on the genetic and clinical profile of this new subtype via RNA sequencing, IHC, array CGH, and FISH analysis of 33 MAP3K8-fused spitzoid neoplasms. Our MAP3K8 break apart FISH probe was used to detect MAP3K8 rearrangements.
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Product Details

Product: MAP3K8 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: MAP3K8-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping