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KMT2A Break Apart FISH Probe

Empire Genomics’ KMT2A Break Apart FISH Probe is designed to flank the KMT2A gene and is typically used for detecting KMT2A rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
KMT2ABA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
KMT2ABA-20-AQOR 20 (40 μL) 200 μL
KMT2ABA-20-GOGR 20 (40 μL) 200 μL
KMT2ABA-20-GORE 20 (40 μL) 200 μL
KMT2ABA-20-GRGO 20 (40 μL) 200 μL
KMT2ABA-20-GRRE 20 (40 μL) 200 μL
KMT2ABA-20-ORGR 20 (40 μL) 200 μL
KMT2ABA-20-REGO 20 (40 μL) 200 μL
KMT2ABA-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

Gene Details

Gene Symbol: KMT2A

Gene Name: Lysine Methyltransferase 2A

Chromosome: CHR11: 118436489-118526831

Locus: 11q23.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: KMT2A FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: KMT2A-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping