KMT2A Break Apart FISH Probe
Empire Genomics’ KMT2A Break Apart FISH Probe is designed to flank the KMT2A gene and is typically used for detecting KMT2A rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KMT2ABA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| KMT2ABA-20-AQOR | 20 (40 μL) | 200 μL |
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| KMT2ABA-20-GOGR | 20 (40 μL) | 200 μL |
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| KMT2ABA-20-GORE | 20 (40 μL) | 200 μL |
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| KMT2ABA-20-GRGO | 20 (40 μL) | 200 μL |
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| KMT2ABA-20-GRRE | 20 (40 μL) | 200 μL |
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| KMT2ABA-20-ORGR | 20 (40 μL) | 200 μL |
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| KMT2ABA-20-REGO | 20 (40 μL) | 200 μL |
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| KMT2ABA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
Gene Details
Gene Symbol: KMT2A
Gene Name: Lysine Methyltransferase 2A
Chromosome: CHR11: 118436489-118526831
Locus: 11q23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: KMT2A FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: KMT2A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping