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KIR2DL4 FISH Probe

The KIR2DL4 FISH probe is designed to hybridize to the KIR2DL4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

SKU Test Kits Buffer Dye Color Order Now
KIR2DL4-20-OR  (Standard Design) 20 (40 μL) 200 μL
KIR2DL4-20-RE 20 (40 μL) 200 μL
KIR2DL4-20-GO 20 (40 μL) 200 μL
KIR2DL4-20-GR 20 (40 μL) 200 μL
KIR2DL4-20-AQ 20 (40 μL) 200 μL
KIR2DL4-20-DIG 20 (40 μL) 200 μL
KIR2DL4-20-BIO 20 (40 μL) 200 μL

Gene Summary

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. [provided by RefSeq, Jul 2016]

Gene Details

Gene Symbol: KIR2DL4

Gene Name: Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 4

Chromosome: CHR19_gl000209_random: 57208-68123

Locus: 19q13.42

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Scientific Citations

There are currently no FISH related citations for this gene.

Product Details

Product: KIR2DL4 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: KIR2DL4-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping