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JAK2 Break Apart FISH Probe

Empire Genomics’ JAK2 Break Apart FISH Probe is designed to flank the JAK2 gene and is typically used for detecting JAK2 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
JAK2BA-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
JAK2BA-20-AQOR 20 (40 μL) 200 μL
JAK2BA-20-GOGR 20 (40 μL) 200 μL
JAK2BA-20-GORE 20 (40 μL) 200 μL
JAK2BA-20-GRGO 20 (40 μL) 200 μL
JAK2BA-20-GROR 20 (40 μL) 200 μL
JAK2BA-20-GRRE 20 (40 μL) 200 μL
JAK2BA-20-REGO 20 (40 μL) 200 μL
JAK2BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: JAK2

Gene Name: Janus Kinase 2

Chromosome: CHR9: 4985244-5128183

Locus: 9p24.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

JAK2 double minutes with resultant simultaneous amplification of JAK2 and CD274 in a therapy-related myelodysplastic syndrome evolving into an acute myeloid leukaemia

Amplification with double minutes (DM) of the JAK2 gene could potentially accelerate the progression of leukemia. FISH analysis was used in conjunction with SNP microarray to observe the effects of the amplification. FISH was performed using our JAK2 probe, showing multiple copies of JAK2 residing on the DMs. It was concluded that amplification of JAK2 could indeed contribute to progression of the disease.
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First Case of Double T-Cell Receptor Alpha/Delta Rearrangements of t(11;14) and inv(14) and Subsequent JAK2 Rearrangement in a Patient with T-Cell Acute Lymphoblastic Leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is characterized by translocations of oncogenic transcription factor genes and T-cell receptor loci. This study reported the first case of T-ALL with TCR alpha/delta (TRA/D) locus rearrangements associated with t(11;14)(p13;q11.2), inv(14)(q11.2q32), and clonal evolution of JAK2 rearrangement. Our JAK2 break-apart probe was used to detect a novel JAK2 translocation, t(8;9)(p22;p24), in the subject under study. As the patient tested negative for JAK2 rearrangements at diagnosis, the translocation must have developed during disease progression.
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The diagnostic challenges and clinical course of a myeloid/lymphoid neoplasm with eosinophilia and ZBTB20-JAK2 gene fusion presenting as B-lymphoblastic leukemia

JAK2 rearrangements are hallmarks of both Ph-Like B-cell ALL and myeloid/lymphoid neoplasms with eosinophilia and gene rearrangements (MLN-EGR). This study used our JAK2 break-apart probe to discover a new JAK2 fusion - ZBTB20/JAK2 - in a patient with B-ALL with eosinophilia. The team found that her disease originated with a JAK2-rearranged myeloid neoplasm that developed into B-ALL.
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Product Details

Product: JAK2 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: JAK2-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping