HIKESHI FISH Probe
The HIKESHI FISH probe is designed to hybridize to the HIKESHI gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HIKESHI-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HIKESHI-20-RE | 20 (40 μL) | 200 μL |  |
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| HIKESHI-20-GO | 20 (40 μL) | 200 μL |  |
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| HIKESHI-20-GR | 20 (40 μL) | 200 μL |  |
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| HIKESHI-20-AQ | 20 (40 μL) | 200 μL |  |
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| HIKESHI-20-DIG | 20 (40 μL) | 200 μL |  |
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| HIKESHI-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress. [provided by RefSeq, Apr 2016]
Gene Details
Gene Symbol: HIKESHI
Gene Name: Hikeshi, Heat Shock Protein Nuclear Import Factor
Chromosome: CHR11: 86302210-86345942
Locus: 11q14.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HIKESHI FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HIKESHI-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping