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HECW2 FISH Probe

The HECW2 FISH probe is designed to hybridize to the HECW2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
HECW2-20-OR  (Standard Design) 20 (40 μL) 200 μL
HECW2-20-RE 20 (40 μL) 200 μL
HECW2-20-GO 20 (40 μL) 200 μL
HECW2-20-GR 20 (40 μL) 200 μL
HECW2-20-AQ 20 (40 μL) 200 μL
HECW2-20-DIG 20 (40 μL) 200 μL
HECW2-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Gene Details

Gene Symbol: HECW2

Gene Name: HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2

Chromosome: CHR2: 197063976-197457335

Locus: 2q32.3

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: HECW2 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: HECW2-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping