GPX3 FISH Probe
The GPX3 FISH probe is designed to hybridize to the GPX3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GPX3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| GPX3-20-RE | 20 (40 μL) | 200 μL |  |
|
| GPX3-20-GO | 20 (40 μL) | 200 μL |  |
|
| GPX3-20-GR | 20 (40 μL) | 200 μL |  |
|
| GPX3-20-AQ | 20 (40 μL) | 200 μL |  |
|
| GPX3-20-DIG | 20 (40 μL) | 200 μL |  |
|
| GPX3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Gene Details
Gene Symbol: GPX3
Gene Name: Glutathione Peroxidase 3
Chromosome: CHR5: 150399998-150408554
Locus: 5q33.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: GPX3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: GPX3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping