GNAS Break Apart FISH Probe
Empire Genomics’ GNAS Break Apart FISH Probe is designed to flank the GNAS gene and is typically used for detecting GNAS rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GNASBA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GNASBA-20-AQOR | 20 (40 μL) | 200 μL |
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| GNASBA-20-GOGR | 20 (40 μL) | 200 μL |
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| GNASBA-20-GORE | 20 (40 μL) | 200 μL |
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| GNASBA-20-GRGO | 20 (40 μL) | 200 μL |
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| GNASBA-20-GROR | 20 (40 μL) | 200 μL |
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| GNASBA-20-GRRE | 20 (40 μL) | 200 μL |
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| GNASBA-20-REGO | 20 (40 μL) | 200 μL |
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| GNASBA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
Gene Details
Gene Symbol: GNAS
Gene Name: GNAS Complex Locus
Chromosome: CHR20: 57414794-57486250
Locus: 20q13.32
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: GNAS FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: GNAS-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping