FBXW4 FISH Probe
The FBXW4 FISH probe is designed to hybridize to the FBXW4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FBXW4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| FBXW4-20-RE | 20 (40 μL) | 200 μL |  |
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| FBXW4-20-GO | 20 (40 μL) | 200 μL |  |
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| FBXW4-20-GR | 20 (40 μL) | 200 μL |  |
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| FBXW4-20-AQ | 20 (40 μL) | 200 μL |  |
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| FBXW4-20-DIG | 20 (40 μL) | 200 μL |  |
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| FBXW4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: FBXW4
Gene Name: F-box And WD Repeat Domain Containing 4
Chromosome: CHR10: 103370420-103454743
Locus: 10q24.32
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: FBXW4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: FBXW4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping