DUT FISH Probe
The DUT FISH probe is designed to hybridize to the DUT gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DUT-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| DUT-20-RE | 20 (40 μL) | 200 μL |  |
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| DUT-20-GO | 20 (40 μL) | 200 μL |  |
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| DUT-20-GR | 20 (40 μL) | 200 μL |  |
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| DUT-20-AQ | 20 (40 μL) | 200 μL |  |
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| DUT-20-DIG | 20 (40 μL) | 200 μL |  |
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| DUT-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: DUT
Gene Name: Deoxyuridine Triphosphatase
Chromosome: CHR15: 48623620-48635570
Locus: 15q21.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: DUT FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: DUT-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping