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DUT FISH Probe

The DUT FISH probe is designed to hybridize to the DUT gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

SKU Test Kits Buffer Dye Color Order Now
DUT-20-OR  (Standard Design) 20 (40 μL) 200 μL
DUT-20-RE 20 (40 μL) 200 μL
DUT-20-GO 20 (40 μL) 200 μL
DUT-20-GR 20 (40 μL) 200 μL
DUT-20-AQ 20 (40 μL) 200 μL
DUT-20-DIG 20 (40 μL) 200 μL
DUT-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: DUT

Gene Name: Deoxyuridine Triphosphatase

Chromosome: CHR15: 48623620-48635570

Locus: 15q21.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: DUT FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: DUT-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping