CHRNA7 FISH Probe
The CHRNA7 FISH probe is designed to hybridize to the CHRNA7 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CHRNA7-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| CHRNA7-20-RE | 20 (40 μL) | 200 μL |  |
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| CHRNA7-20-GO | 20 (40 μL) | 200 μL |  |
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| CHRNA7-20-GR | 20 (40 μL) | 200 μL |  |
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| CHRNA7-20-AQ | 20 (40 μL) | 200 μL |  |
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| CHRNA7-20-DIG | 20 (40 μL) | 200 μL |  |
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| CHRNA7-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Gene Details
Gene Symbol: CHRNA7
Gene Name: Cholinergic Receptor Nicotinic Alpha 7 Subunit
Chromosome: CHR15: 32322690-32462384
Locus: 15q13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: CHRNA7 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: CHRNA7-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping