BPTF FISH Probe
The BPTF FISH probe is designed to hybridize to the BPTF gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BPTF-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| BPTF-20-RE | 20 (40 μL) | 200 μL |  |
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| BPTF-20-GO | 20 (40 μL) | 200 μL |  |
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| BPTF-20-GR | 20 (40 μL) | 200 μL |  |
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| BPTF-20-AQ | 20 (40 μL) | 200 μL |  |
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| BPTF-20-DIG | 20 (40 μL) | 200 μL |  |
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| BPTF-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: BPTF
Gene Name: Bromodomain PHD Finger Transcription Factor
Chromosome: CHR17: 65821779-65980494
Locus: 17q24.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: BPTF FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: BPTF-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping