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ATF1 Break Apart FISH Probe

Empire Genomics’ ATF1 Break Apart FISH Probe is designed to flank the ATF1 gene and is typically used for detecting ATF1 rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
ATF1BA-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ATF1BA-20-AQOR 20 (40 μL) 200 μL
ATF1BA-20-GOGR 20 (40 μL) 200 μL
ATF1BA-20-GORE 20 (40 μL) 200 μL
ATF1BA-20-GRGO 20 (40 μL) 200 μL
ATF1BA-20-GROR 20 (40 μL) 200 μL
ATF1BA-20-GRRE 20 (40 μL) 200 μL
ATF1BA-20-REGO 20 (40 μL) 200 μL
ATF1BA-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]

Gene Details

Gene Symbol: ATF1

Gene Name: Activating Transcription Factor 1

Chromosome: CHR12: 51157788-51214943

Locus: 12q13.12

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Detection of specific gene rearrangements by fluorescence in situ hybridization in 16 cases of clear cell sarcoma of soft tissue and 6 cases of clear cell sarcoma-like gastrointestinal tumor

Clear cell sarcoma can be identified by the fusion of EWSR1 to CREB genes like ATF1 and CREB1. FISH was used to analyze the arrangements of the genes. FISH analysis was performed with our dual-color break apart probes for ATF1, CREB1, and CREM. It was determined that EWSR1-ATF1 fusion was primarily found in clear cell sarcoma in soft tissue, while EWSR1-CREB1 fusion was found in clear cell sarcoma-like gastrointestinal tumors.
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Product Details

Product: ATF1 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: ATF1-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping