APH1A Break Apart FISH Probe
Empire Genomics’ APH1A Break Apart FISH Probe is designed to flank the APH1A gene and is typically used for detecting APH1A rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APH1ABA-20-GROR (Standard Design) | 20 (40 μL) | 200 μL |
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| APH1ABA-20-AQOR | 20 (40 μL) | 200 μL |
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| APH1ABA-20-GOGR | 20 (40 μL) | 200 μL |
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| APH1ABA-20-GORE | 20 (40 μL) | 200 μL |
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| APH1ABA-20-GRGO | 20 (40 μL) | 200 μL |
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| APH1ABA-20-GRRE | 20 (40 μL) | 200 μL |
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| APH1ABA-20-ORGR | 20 (40 μL) | 200 μL |
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| APH1ABA-20-REGO | 20 (40 μL) | 200 μL |
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| APH1ABA-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011]
Gene Details
Gene Symbol: APH1A
Gene Name: Aph-1 Homolog A, Gamma-secretase Subunit
Chromosome: CHR1: 150237798-150241609
Locus: 1q21.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: APH1A FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: APH1A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping