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ALK Break Apart FISH Probe

Empire Genomics’ ALK Break Apart FISH Probe is designed to flank the ALK gene and is typically used for detecting ALK rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
ALKBA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
ALKBA-20-AQOR 20 (40 μL) 200 μL
ALKBA-20-GOGR 20 (40 μL) 200 μL
ALKBA-20-GORE 20 (40 μL) 200 μL
ALKBA-20-GRGO 20 (40 μL) 200 μL
ALKBA-20-GRRE 20 (40 μL) 200 μL
ALKBA-20-ORGR 20 (40 μL) 200 μL
ALKBA-20-REGO 20 (40 μL) 200 μL
ALKBA-20-REGR 20 (40 μL) 200 μL

Gene Summary

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

Gene Details

Gene Symbol: ALK

Gene Name: ALK Receptor Tyrosine Kinase

Chromosome: CHR2: 29415639-30144477

Locus: 2p23.2-p23.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Atypical Spitzoid Neoplasms in Childhood: A Molecular and Outcome Study

Atypical spitzoid neoplasms (APNs) are primarily pediatric lesions characterized by their intermediate features; clinically and histopathologically, they fall somewhere between benign spitz nevi and malignant melanoma. The genetics of these tumors are still poorly understood. In this study, 34 APNs were analyzed using FISH and IHC. Our ALK, BRAF, and NTRK1 break-apart FISH probes were used to detect rearrangements of the genes .
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Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas

While studies are plentiful on adult gliomas, infant cases are historically understudied. This team sought to account for that lack of data by analyzing glioma biopsies from 150 infants. As part of genetic profiling, our ALK break apart probe was used to detect ALK rearrangements. The team was able to divide the tumors into three genetic subtypes that were tightly tied to clinical outcome. They also found that many of the tumors harbored just a single oncogene, evidence that infant gliomas are usually single driver tumors.
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ALK-rearranged renal cell carcinomas in Polish population

Since the first report 2010, 22 cases of ALK-rearranged renal cell carcinoma (RCC) have been described. This study screened over 1000 Polish RCC patients for ALK translocations using IHC followed by FISH with our ALK break apart FISH probe. Only 31 cases were considered potentially positive or indeterminable by IHC; of these, none tested positive for ALK rearrangement with FISH. These results suggests that the mutation might be related to ethnicity, warranting further investigation into its prevalence in other ethnicities.
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Product Details

Product: ALK FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: ALK-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping