Empire Genomics’ ACTL6A Break Apart FISH Probe is designed to flank the ACTL6A gene and is typically used for detecting ACTL6A rearrangements
such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in orange and green by
meet your needs.
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Symbol: ACTL6A
Gene Name: Actin Like 6A
Chromosome: CHR3: 179280707-179306193
Our database currently has no diseases associated with the ACTL6A gene.
FISH Probe Protocols
Protocol, Procedure, or Form Name
There are currently no FISH related citations for this gene.