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Primary Mammary Analogue Secretory Carcinoma of the Lung: A Case Report

2017-11-02 14:28:28

Human Pathology https://doi.org/10.1016/j.humpath.2017.10.027

Tao Huang MD, PhD; Jonathan B. McHugh, MD; Gerald J.Berry, MD; Jeffrey L. Myers, MD


a: Department of Pathology, University of Michigan, Ann Arbor, MI, 48109

b: Department of Pathology, Stanford University Medical Center, Stanford, CA, 94304



Abstract


Mammary analogue secretory carcinoma (MASC) is a recently discovered salivary gland tumor described mostly in the major salivary glands and occasionally in the skin. We report a primary endobronchial tumor with histology, immunophenotype, and ETV6 rearrangement characteristic of MASC in a 62-year-old woman. The diagnosis was initially made on a transbronchial biopsy with FISH confirmation of ETV6 rearrangement. The patient underwent lobectomy demonstrating a large endobronchial mass. To our knowledge, this is the first report of MASC arising as a primary pulmonary tumor. This tumor was unusual in that it is the largest (8.5 cm) MASC ever reported, showed an increased mitotic count (6/10 HPF) without high grade cytology, and presented with advanced stage disease that included visceral pleural invasion and lymph node metastasis.






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