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MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer

2016-09-21 19:27:56

The Journal of Pathology/span>; 21 September 2014: DOI:10.1002/path.4823


Yan Sun, Ping Ji, Tao Chen, Xinhui Zhou, Da Yang, Yuhong Guo, Yuexin Liu ,Limei Hu, DianrenXia, YanxueLiu, Asha S.Multani, IlyaShmulevich, Raju Kucherlapati, Scott Kopetz, Anil K. Sood, Stanley R. Hamilton, Baocun Sun, Wei Zhang



Abstract


The gene encoding Migration and Invasion Inhibitory Protein (MIIP), located on 1p36.22, is a potential tumour suppressor gene in glioma. In this study, we aimed to explore the role and mechanism of action of MIIP in colorectal cancer (CRC). MIIP protein expression gradually decreased along the colorectal adenoma-carcinoma sequence and was negatively correlated with lymph node and distant metastasis in 526 colorectal tissue samples (P

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