PPFIA1-SHANK2 Fusion FISH Probe
The PPFIA1-SHANK2 Fusion FISH Probe is used to confirm a fusion of the PPFIA1 and SHANK2 genes. The fusion of the PPFIA1 and SHANK2 genes has been associated with Bladder Urothelial Carcinoma, Lung Squamous Cell Carcinoma, and Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PPFIA1-SHANK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PPFIA1-SHANK2-20-AQAQ | 20 (40 μL) | 200 μL |
|
PPFIA1 Gene Summary
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: PTPRF Interacting Protein Alpha 1
Chromosome: CHR11: 70116822 -70230502
Locus: 11q13.3
SHANK2 Gene Summary
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Name: SH3 And Multiple Ankyrin Repeat Domains 2
Chromosome: CHR11: 70313960 -70935808
Locus: 11q13.3-q13.4
Gene Diseases
The PPFIA1 SHANK2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Bladder Urothelial Carcinoma |
| Lung Squamous Cell Carcinoma |
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|