NUP98-RHOG Fusion FISH Probe
The NUP98-RHOG Fusion FISH Probe is used to confirm a fusion of the NUP98 and RHOG genes. The fusion of the NUP98 and RHOG genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUP98-RHOG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-RERE | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-REOR | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-REGO | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-REGR | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-REAQ | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-ORRE | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-OROR | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-ORGO | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-GORE | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-GOOR | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-GOGO | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-GOGR | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-GRRE | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-GROR | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-GRGO | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-GRGR | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-AQRE | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-AQOR | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-AQGO | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-AQGR | 20 (40 μL) | 200 μL |
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| NUP98-RHOG-20-AQAQ | 20 (40 μL) | 200 μL |
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RHOG Gene Summary
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]
Gene Name: Ras Homolog Family Member G
Chromosome: CHR11: 3848207 -3862213
Locus: 11p15.4
NUP98 Gene Summary
Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]
Gene Name: Nucleoporin 98
Chromosome: CHR11: 3696239 -3819022
Locus: 11p15.4
Gene Diseases
The NUP98 RHOG Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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