LSP1-SYT8 Fusion FISH Probe
The LSP1-SYT8 Fusion FISH Probe is used to confirm a fusion of the LSP1 and SYT8 genes. The fusion of the LSP1 and SYT8 genes has been associated with Adrenocortical Carcinoma, and Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LSP1-SYT8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-RERE | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-REOR | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-REGO | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-REGR | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-REAQ | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-ORRE | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-OROR | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-ORGO | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-ORAQ | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-GORE | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-GOOR | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-GOGO | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-GOGR | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-GOAQ | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-GRRE | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-GROR | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-GRGO | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-GRGR | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-GRAQ | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-AQRE | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-AQOR | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-AQGO | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-AQGR | 20 (40 μL) | 200 μL |
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| LSP1-SYT8-20-AQAQ | 20 (40 μL) | 200 μL |
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LSP1 Gene Summary
This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Lymphocyte-specific Protein 1
Chromosome: CHR11: 1874199 -1913493
Locus: 11p15.5
SYT8 Gene Summary
This gene encodes a member of the synaptotagmin protein family. Synaptotagmins are membrane proteins that are important in neurotransmission and hormone secretion, both of which involve regulated exocytosis. Expression of the encoded protein in human pancreatic islets has been connected to activity of the promoter for the insulin gene, on the same chromosome several hundred kilobases away (PMID: 21336277 and 22928559). This association would link response to gluclose to insulin secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Gene Name: Synaptotagmin 8
Chromosome: CHR11: 1855673 -1858750
Locus: 11p15.5
Gene Diseases
The LSP1 SYT8 Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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