GMDS-KIF6 Fusion FISH Probe
The GMDS-KIF6 Fusion FISH Probe is used to confirm a fusion of the GMDS and KIF6 genes. The fusion of the GMDS and KIF6 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GMDS-KIF6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-RERE | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-REOR | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-REGO | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-REGR | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-OROR | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-GORE | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-GROR | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| GMDS-KIF6-20-AQAQ | 20 (40 μL) | 200 μL |
|
GMDS Gene Summary
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
Gene Name: GDP-mannose 4,6-dehydratase
Chromosome: CHR6: 1624040 -2245846
Locus: 6p25.3
KIF6 Gene Summary
This gene encodes a member of a family of molecular motors which are involved in intracellular transport of protein complexes, membrane organelles, and messenger ribonucleic acid along microtubules. Kinesins function as homodimeric molecules with two N-terminal head domains that move along microtubules and two C-terminal tail domains that interact with the transported cargo, either directly or indirectly, through adapter molecules. This gene is ubiquitously expressed in coronary arteries and other vascular tissue. A naturally occurring mutation in this gene is associated with coronary heart disease. [provided by RefSeq, May 2017]
Gene Name: Kinesin Family Member 6
Chromosome: CHR6: 39302875 -39693181
Locus: 6p21.2
Gene Diseases
The GMDS KIF6 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|