GMDS-CCND3 Fusion FISH Probe
The GMDS-CCND3 Fusion FISH Probe is used to confirm a fusion of the GMDS and CCND3 genes. The fusion of the GMDS and CCND3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GMDS-CCND3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-RERE | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-REOR | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-REGO | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-REGR | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-REAQ | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-ORRE | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-OROR | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-ORGO | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-ORAQ | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-GORE | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-GOOR | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-GOGO | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-GOGR | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-GOAQ | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-GRRE | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-GROR | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-GRGO | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-GRGR | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-GRAQ | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-AQRE | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-AQOR | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-AQGO | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-AQGR | 20 (40 μL) | 200 μL |
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| GMDS-CCND3-20-AQAQ | 20 (40 μL) | 200 μL |
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CCND3 Gene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Name: Cyclin D3
Chromosome: CHR6: 41902670 -42016610
Locus: 6p21.1
GMDS Gene Summary
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
Gene Name: GDP-mannose 4,6-dehydratase
Chromosome: CHR6: 1624040 -2245846
Locus: 6p25.3
Gene Diseases
The GMDS CCND3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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