GLUL-STAT6 Fusion FISH Probe
The GLUL-STAT6 Fusion FISH Probe is used to confirm a fusion of the GLUL and STAT6 genes. The fusion of the GLUL and STAT6 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GLUL-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-RERE | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-REOR | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-REGO | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-REGR | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-OROR | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-GORE | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-GROR | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
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| GLUL-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
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GLUL Gene Summary
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: Glutamate-ammonia Ligase
Chromosome: CHR1: 182350838 -182361341
Locus: 1q25.3
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The GLUL STAT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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