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GLI2-SPOP Fusion FISH Probe

The GLI2-SPOP Fusion FISH Probe is used to confirm a fusion of the GLI2 and SPOP genes. The fusion of the GLI2 and SPOP genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
GLI2-SPOP-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
GLI2-SPOP-20-RERE 20 (40 μL) 200 μL
GLI2-SPOP-20-REOR 20 (40 μL) 200 μL
GLI2-SPOP-20-REGO 20 (40 μL) 200 μL
GLI2-SPOP-20-REGR 20 (40 μL) 200 μL
GLI2-SPOP-20-REAQ 20 (40 μL) 200 μL
GLI2-SPOP-20-ORRE 20 (40 μL) 200 μL
GLI2-SPOP-20-OROR 20 (40 μL) 200 μL
GLI2-SPOP-20-ORGO 20 (40 μL) 200 μL
GLI2-SPOP-20-ORAQ 20 (40 μL) 200 μL
GLI2-SPOP-20-GORE 20 (40 μL) 200 μL
GLI2-SPOP-20-GOOR 20 (40 μL) 200 μL
GLI2-SPOP-20-GOGO 20 (40 μL) 200 μL
GLI2-SPOP-20-GOGR 20 (40 μL) 200 μL
GLI2-SPOP-20-GOAQ 20 (40 μL) 200 μL
GLI2-SPOP-20-GRRE 20 (40 μL) 200 μL
GLI2-SPOP-20-GROR 20 (40 μL) 200 μL
GLI2-SPOP-20-GRGO 20 (40 μL) 200 μL
GLI2-SPOP-20-GRGR 20 (40 μL) 200 μL
GLI2-SPOP-20-GRAQ 20 (40 μL) 200 μL
GLI2-SPOP-20-AQRE 20 (40 μL) 200 μL
GLI2-SPOP-20-AQOR 20 (40 μL) 200 μL
GLI2-SPOP-20-AQGO 20 (40 μL) 200 μL
GLI2-SPOP-20-AQGR 20 (40 μL) 200 μL
GLI2-SPOP-20-AQAQ 20 (40 μL) 200 μL

GLI2 Gene Summary

This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]

Gene Name: GLI Family Zinc Finger 2

Chromosome: CHR2: 121554866 -121750229

Locus: 2q14.2

SPOP Gene Summary

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Gene Name: Speckle Type BTB/POZ Protein

Chromosome: CHR17: 47676245 -47755525

Locus: 17q21.33

Gene Diseases

The GLI2 SPOP Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.