GLI2-MARCO Fusion FISH Probe
The GLI2-MARCO Fusion FISH Probe is used to confirm a fusion of the GLI2 and MARCO genes. The fusion of the GLI2 and MARCO genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GLI2-MARCO-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-RERE | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-REOR | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-REGO | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-REGR | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-REAQ | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-ORRE | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-OROR | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-ORGO | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-ORAQ | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-GORE | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-GOOR | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-GOGO | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-GOGR | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-GOAQ | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-GRRE | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-GROR | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-GRGO | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-GRGR | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-GRAQ | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-AQRE | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-AQOR | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-AQGO | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-AQGR | 20 (40 μL) | 200 μL |
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| GLI2-MARCO-20-AQAQ | 20 (40 μL) | 200 μL |
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GLI2 Gene Summary
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
Gene Name: GLI Family Zinc Finger 2
Chromosome: CHR2: 121554866 -121750229
Locus: 2q14.2
MARCO Gene Summary
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]
Gene Name: Macrophage Receptor With Collagenous Structure
Chromosome: CHR2: 119699744 -119752236
Locus: 2q14.2
Gene Diseases
The GLI2 MARCO Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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