GGA2-PRKCB Fusion FISH Probe
The GGA2-PRKCB Fusion FISH Probe is used to confirm a fusion of the GGA2 and PRKCB genes. The fusion of the GGA2 and PRKCB genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| GGA2-PRKCB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-RERE | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-REOR | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-REGO | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-REGR | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-REAQ | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-ORRE | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-OROR | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-ORGO | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-ORAQ | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-GORE | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-GOOR | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-GOGO | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-GOGR | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-GOAQ | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-GRRE | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-GROR | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-GRGO | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-GRGR | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-GRAQ | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-AQRE | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-AQOR | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-AQGO | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-AQGR | 20 (40 μL) | 200 μL |
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| GGA2-PRKCB-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKCB Gene Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase C Beta
Chromosome: CHR16: 23847299 -24231932
Locus: 16p12.2-p12.1
GGA2 Gene Summary
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]
Gene Name: Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 2
Chromosome: CHR16: 23474862 -23521815
Locus: 16p12.2
Gene Diseases
The GGA2 PRKCB Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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