ACACA-HTRA4 Fusion FISH Probe
The ACACA-HTRA4 Fusion FISH Probe is used to confirm a fusion of the ACACA and HTRA4 genes. The fusion of the ACACA and HTRA4 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACACA-HTRA4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-RERE | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-REOR | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-REGO | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-REGR | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-REAQ | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-ORRE | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-OROR | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-ORGO | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-GORE | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-GOOR | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-GOGO | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-GOGR | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-GRRE | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-GROR | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-GRGO | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-GRGR | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-AQRE | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-AQOR | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-AQGO | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-AQGR | 20 (40 μL) | 200 μL |
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| ACACA-HTRA4-20-AQAQ | 20 (40 μL) | 200 μL |
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ACACA Gene Summary
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Acetyl-CoA Carboxylase Alpha
Chromosome: CHR17: 35441926 -35766902
Locus: 17q12
HTRA4 Gene Summary
This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]
Gene Name: HtrA Serine Peptidase 4
Chromosome: CHR8: 38831667 -38846181
Locus: 8p11.22
Gene Diseases
The ACACA HTRA4 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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